Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors to cognitive neurodevelopmental disorders. The book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onwards with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders. Discusses links between brain development, gene expression, and brain functionCovers neural stem cells, proliferation, migration, differentiation, and neurogenesisIncludes brain mapping, brain plasticity, epigenetics, neuroimmunology and moreProvides insight into causation and brain function in autism. attention deficit disorder, and learning disabilitiesExamines impact of society and environmental factors on mental health INDICE: Section I Brain, early development cortices, architecture, cell types, connectivity, networks Early brain development Development and evolution of cerebral and cerebellar cortex White matter development and maturation of connections Brain size Emergence of functional architecture Architectonic mapping beyond Brodman Neuronal cells organization according to transcription Association cortices Cell maps neuronal cell types, classification Development of network hubs Functional and structural connectivity Myelo-architecture Connectome and network theory Hubs modules nodes Microstructure connectomics Dendrites, dendritic spines, spine patterns Networks Distinct metabolic and cytoarchitecture and increased dendritic density in hubs Oligodendrocytes and astrocytes Section II Neurotransmitters, Neuromodulators. Synapses Neurotransmitters and neuroreceptors, neuromodulators Signalling downstream of receptors Synapses, structure, diversity Post-synaptic interactome Dendrites and transmission Ion channels and channel dynamics Lipids and synaptic function Section III. Brain Mapping Mapping structural connections forms of imaging Functional connectivity and brain metabolic activity Receptor autoradiography. NIH Connectome project Section IV. Brain Plasticity Neuroplasticity Brain derived neurotrophic factors Dendritic spine dynamics and synaptic plasticity Oligodendrocyte lineage and brain plasticity Mitochondria and brain energy Metabolism and circadian rhythm Section V. Gene Expression and Regulation in Brain and Epigenetics Signalling pathways Gene transcription Epigenetics and regulation of expression 3D genome and regulation chromatin modifications and dynamics Epigenetics, environmental factors Genomic imprinting and defects potentially impacting development Genomic regulatory elements and transcription Section VI. Neuroimmunology Neuro-immunology past present and future Brain immune system Micro glia and functions related to immune functions Cytokines and neuromodulators Defined neuroimmune diseases Section VII. Neurodevelopmental, Neurocognitive and Behavioral Disorders ICD 11 DSM 6 Classification of Pediatric disorders Neuronal activity post-natal neurogenesis and gliogenesis Genomic copy number variants in autism and in neurocognitive disorders Genotype phenotype correlation in copy number disorders Early brain and behavior and development in autism Functional brain connectome in autism Idiopathic autism, studies in derived in pluripotent stem cell derived neurons Gene sequence studies and genome wide association studies in autism Autism genetic and phenotypic heterogeneity Specific genetic defects and Syndromic autism spectrum disorders Non-syndromic autism rare variants Common variants that impact risk in autism spectrum disorders Beyond the exome Noncoding genome and enhancers in neurodevelopment. Regulatory elements in neurodevelopmental disorders Chromosome 22q11.2 microdeletion and microduplication and consequent disorders Attention deficit disorders risk variants Cross over in neurobehavioral disorders Intellectual disability inborn errors of metabolism impacting risk nuclear and mitochondrial defects Therapeutic advances Section VIII Psychiatric diseases DSM and ICD classifications on basis of clinical manifestations Architectural and cellular elements in psychiatric disorders Connectome disruptions in psychiatric diseases Shared heritability in psychiatric disorders NIH brain initiative Future of Psychiatry Treatment of Psychiatric disorders medications, Neurobehavioral therapy Microbiome and potential gut brain interactions Neuromodulation techniques Ethics and Neuroethics in the Brain Initiative Section IX Health and Wellbeing Environmental factors and epigenetics Nutritional Deficiencies Environment and Stress systems involved in stress responses Social Cognition Ecosystem Ecotherapy Enhancing Neuroplasticity, promoting Resilience Section X Brain and Mind Concepts and Ideas Environment, Learning, Experience Cultures and Societies
- ISBN: 978-0-12-821913-3
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 300
- Fecha Publicación: 01/06/2021
- Nº Volúmenes: 1
- Idioma: Inglés