Neurotherapeutics in the Era of Translational Medicine

Neurotherapeutics in the Era of Translational Medicine focuses on the remarkable progress made in treating neurologic disorders which heretofore have been considered incurable. The book represents a celebration of this unique epoch in America that dates from the 1980's, when it became possible to clone genes, and perhaps more importantly, with the sequencing of the entire human genome. Chapters include translational research in potential therapies for Alzheimer's Disease, Amyotrophic Lateral Sclerosis?, Spinal Muscular Atrophy, Huntington's disease, Multiple Sclerosis, Parkinson's Disease Myotonic Dystrophy, and Glioblastoma. The book also discusses general concerns of clinical trials, like trial designs and ethical issues. Neuroscientists, pharmacologists, and clinicians, especially neurologists and neurosurgeons will find this book useful. Comprehensive review on the progress of translational research in neurotherapeutics for neurologic disordersDiscusses important issues in clinical trials such as design and ethical issuesWritten for neuroscientists, neurologists and pharmacologists INDICE: 1. Introduction. The Era of Translational Medicine 2. Targeting Tau for the Treatment of Alzheimer's Disease 3. Downregulation of SOD-1: A Treatment Target for Familial ALS 4. Unraveling the Complicated Biology of C9ORF in ALS 5. Leveraging an In Vitro Model to Design a Treatment for Sporadic ALS 6. Stem Cell Trials for ALS 7. Amyloid Neuropathy: transthyretrin amyloidogenesis inhibitors 8. The Advent of Monoclonal Antibodies for the Treatment of Multiple Sclerosis 9. The Treatment of Spinal Muscular Atrophy with Spinraza: A Medical Milestone 10. A Gene-Based Therapy for the Treatment of Spinal Muscular Atrophy 11. Intraspinal Administration of an Antisense Oligonucleotide to Downregulate the Expression of the Huntington Gene 12. An Immunologic Strategy for Targeting Alpha Synuclein in Parkinson's Disease 13. Novel Experimental Approaches to Treating Myotonic Dystrophy 14. Checkpoint Proteins as a Therapeutic Target for the Treatment of Glioblastoma 15. Myasthenia Gravis 16. Identification of Biomarkers for Diagnosing and Monitoring Therapy in the Treatment of Neurologic Disorders 17. Unique Imaging Agents for Evaluating Pathologic Features of CNS Disorders 18. Innovative Clinical Trial Designs for Evaluating Neurotherapeutics 19. Ethical Considerations in the Era of Translational Medicine

• ISBN: 978-0-12-816475-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/09/2020
• Nº Volúmenes: 1
• Idioma: Inglés