Oxidative stress, inflammation and angiogenesis in the metabolic syndrome

Metabolic Syndrome (MS) is a highly prevalent condition in developed countries and is a cluster of several risk factors for type 2 diabetes and cardiovascular disease that includes increased body mass index/waist circumference, visceral obesity, insulin resistance, hyperclycaemia, dyslipidaemia and hypertension, which are all major causes of morbidity and death. This volume provides a critical review and discussion of the knowledge gathered on MS and analyzes theinterplay between oxidative stress, chronic inflammation and angiogenesis features. There is a special focus on recent discoveries and progress toward possible therapeutic strategies, such as the role of glucose transporters within MS; the effects of polyphenols as anti-oxidant, anti-inflammatory and anti-angiogenic compounds. The role of NFkB, nitric oxide synthases, hypoxia-inducible factors, and many other molecules that play a part in the development of oxidative stress and inflammation as well as angiogenesis is also covered. Conceptsand emergent therapeutic interventions Oxidative stress molecules in metabolic syndrome Evidence of Inflammatory pathways in metabolic syndrome Neovascularpathways in metabolic syndrome Cross-talk between the three processes in metabolic syndrome INDICE: Preface. 1. The metabolic syndrome. 2. Oxidative stress: from the 1980’s to recent update. 3. Oxidative stress in metabolic syndrome. 4. Chronicinflammation in metabolic syndrome. Emphasis on adipose tissue. 5. Angiogenesis in the metabolic syndrome. 6. Role of Endothelial Progenitor Cells in the metabolic syndrome. 7. Vascular glucose transport and the metabolic syndrome. 8. Natural polyphenols as anti-oxidant, anti-inflammatory and anti-angiogenic agents. 9. Metabolic syndrome: Practical implications of a concept. Abbreviations. Index.

• ISBN: 978-1-4020-9700-3
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 214
• Fecha Publicación: 01/04/2009
• Nº Volúmenes: 1
• Idioma: Inglés