Reciprocal Translation Between Pathophysiology and Practice in Health and Disease

Reciprocal Translation Between Pathophysiology and Practice in Health and Disease brings a novel perspective, closing the knowledge gap between normal/abnormal physiology. Chapters describe the basic mechanisms underlying a disease or trauma-related response, describe consequences in practice, and provide insights on how to use information to better understand disease outcomes. Other sections explore how these responses are beneficial and driven by similar hormones and inflammatory immune cell derived modulators. This is a must-have resource for those seeking an authoritative and comprehensive understanding on how to treat the basic mechanisms underlying disease or trauma-related responses. Provides an overview of fundamental/foundational content and then goes on to translate the information to more clinically-oriented perspectivesHighlights the benefit of normal pathophysiological response to stress and the misunderstandings surrounding the treatment of this responseExplains how treatment should be adapted to support the inflammatory response and how to treat its inflammatory causeIncludes case studies and slides INDICE: PART I PATHOPHYSIOLOGICAL MECHANISMS IN DISEASE 1. General introduction 2. General principles of the repair mechanism 3. Cardiovascular responses 4. Delivery of essential substrates 5. The role of ectopic lipid metabolism 6. The role of insulin resistance and inflammation 7. The Warburg effect 8. From the gut-liver axis to the biological value of protein: a serendipitous journey 9. Hypoalbuminemia PART II CLINICAL MANIFESTATIONS OF ADAPTIVE PATHOPHYSIOLOGY 10. Cardiovascular stress syndromes 11. Hyperglycemia during severe illness 12. (Pseudo)anemia 13. (Pseudo)-deficiency syndromes 14. Conditions of growth 15. The benefit of the symptoms of Celsus 16. When adaptive pathophysiology fails or creates harm PART III IMPLICATIONS FOR TREATMENT 17. Optimizing clinical trials 18. Nutritional assessment 19. Treatment of symptoms or causes 20. Benefit and concern of the Enhanced Recovery After Surgery program 21. Application of pathophysiological principles in patients with abdominal catastrophe PART IV MECHANISMS PROVIDING INSIGHT IN A FEW ENIGMATIC SYNDROMES 22. The non-paradoxical character of the obesity paradox 23. The conditional role of inflammation in Pregnancy and Cancer 24. Overall conclusions and the viscosity of old insights

• ISBN: 978-0-12-820205-0
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 275
• Fecha Publicación: 01/03/2021
• Nº Volúmenes: 1
• Idioma: Inglés