Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology

Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development. Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants. Covers the exposure and transmission of various toxic xenobiotics substances, including nanomaterials, to humans and their interaction with specific tissues in precipitating the development of cancers Unravels the toxicokinetic and toxicodynamic processes of toxic xenobiotics in bioaccumulation Examines the genetic aberrations in cancer genomes by genetic-environmental interactions in carcinogenesis Explains the biotransformation mechanisms of toxic xenobiotics by gut microbes in humans INDICE: 1. A historical review and future prospective of chemical carcinogenesis2. Role of xenobiotics metabolism in carcinogenesis3. Recalcitrant of toxic xenobiotics and its routes of exposure to human4. Major environmental xenobiotics risk for different cancers5. Toxicokinetic and toxicodynamic of xenobiotics in cancer development 6. Mechanism of oxidative stress in carcinogenesis induced by xenobiotics7. Genotoxic and non-genotoxic activities of cancer-inducing xenobiotics8. Modulation of epigenome by xenobiotics in cancer9. Carcinogenic effects of nanomaterials with emphasis on nanoplastics10. Endocrine disruptor activity of xenobiotics in carcinogenesis11. Environmental exposures (Bisphenol A and phatalates) as xenoestrogens enhance risk for breast cancer12. Biotransformation of toxic xenobiotics by human gut microbiota13. Mechanism of resistance to toxic xenobiotics in human14. Profiling the reactive metabolites of xenobiotics in cancer15. Toxicogenomic for prediction of carcinogenicity of xenobiotic substances

• ISBN: 978-0-323-90560-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 328
• Fecha Publicación: 21/02/2022
• Nº Volúmenes: 1
• Idioma: Inglés