Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds. N-heterocyclic compounds are unique structural units and are important motifs in natural products and pharmaceuticals. They are found at the core of numerous biologically active molecules, and are the focus of novel synthetic approaches. Over the past decade, the copper-catalyzed synthesis of N-heterocycles has achieved remarkable progress with high atom economic strategies, and more recently, copper-catalyzed C-H activation has attracted attention because of its applications in organic synthesis. Copper catalysts show versatile chemical reactivity, and the chemistry of copper is rich in mechanistic possibilities. Oxidation states 0-3 are accessible, and two electrons, as well as one-electron transfer processes are possible. Copper salts can facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts. Copper-facilitated reactions have a long history in organometallic chemistry and new reactions continue to be discovered and developed. In recent years, the area of N-heterocycles synthesis has especially benefited from novel copper facilitated transformations, and this book covers all recent developments. Researchers and students working in the area of synthetic organic chemistry and medicinal chemistry will find this reference useful. Discusses novel synthetic methods developed over the past decade for copper-catalyzed synthesis of N-heterocyclic compoundsCovers the most recent methodologies adapted in synthetic chemistry for applications in natural products and pharmaceuticalsIncludes troubleshooting protocols, as well as the advantages and limitations of each method discussed in detail INDICE: 1. Copper-Catalyzed Synthesis of Aziridines 2. Copper Catalysis for Imidazoles and Pyrazoles 3. Copper catalysis for Triazoles and Tetrazoles 4. Copper Catalysis for Pyridines and Pyrimidines 5. Copper Catalysis for Triazines 6. Copper Catalysis for Pyrazines and Quinoxalines 7. Copper catalysis for Quinolines and Isoquinolines 8. Copper-Mediated Synthesis of Quinazolines and Related Benzodiazines 9. Copper Catalysis for Large Rings 10. Copper Catalysis for Saturated N-Heterocycles via C-H Functionalization 11. Pursuit for Simple and Efficient Ligands Promoting Copper-Catalyzed Type Ullmann Reactions for N-aryl heterocycles and Aromatic Amines 12. Solid Supported Copper for N-heterocycles 13. Copper Catalysis for Biologically Active N-heterocycles
- ISBN: 978-0-12-821263-9
- Editorial: Elsevier
- Encuadernacion: Rústica
- Páginas: 464
- Fecha Publicación: 01/02/2021
- Nº Volúmenes: 1
- Idioma: Inglés