Biocatalysis for pharmaceutical industry: discover, development and manufacturing

Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for Pharmaceutical Industry discusses modern application of biocatalysis in drug discovery, development and manufacturing. Written by leadingexperts, coverage includes enzyme discovery, applications of enzymatic transformations for development of pharmaceutically active compounds, biocatalysis in synthesizing, screening, identifying and characterizing human drug metabolites, combinatorial biosynthesis of active natural products for drug discovery, application of metabolic engineering, optimization of production hosts for efficient development of biopharmaceuticals and applying biocatalysis in green chemistry. INDICE: Preface Chapter 1 Enzyme discovery, development and manufacturing Chapter 2 Enzyme directed evolution and high throughput screening Chapter 3 Retrosynthetic biotransformations and applications of reaction engineering Chapter 4 Practical synthesis of pharmaceutical intermediates using hydrolases Chapter 5 Synthetic applications of ketoreductases and alcohol oxidases Chapter 6 Applications of glycosyltransferases for drug discovery and development Chapter 7 Enantioselective synthesis by aldolases, amine oxidases, transaminases andoxynitrilases Chapter 8 Biosynthesis of drug metabolites for drug discovery Chapter 9 Metabolic engineering for development and manufacturing of pharmaceuticals Chapter 10 Combinatorial biosynthesis of pharmaceutical natural productsand modification Chapter 11 Biopharmaceutical and enzyme production: expression and host optimization Chapter 12 Biocatalysis and green chemistry development of pharmaceuticals

• ISBN: 978-0-470-82314-9
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 250
• Fecha Publicación: 01/11/2008
• Nº Volúmenes: 1
• Idioma: Inglés