Providing the most relevant information available, this work presents in-depth discussions of DNA methylation analysis and cancer, histone modifications and cancer, and other epigenetic aspects of cancer. Examining future directions in cancer research, this text offers a comprehensive overview of current and potential new epigenetics advancements. Back Cover Copy Catalog no. 45792, "Cancer Epigenetics Shelving Guide: Biological Sciences Elucidating" the most-recent advances in the genomic breakthrough of epigenetics, this cutting-edge workcovers a wide array of aspects ranging from the role of epigenetics in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy."Cancer Epigenetics" presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. With stand-alone chapters authored by research pioneers in the field, this definitive resource - discusses the recent advances in the role of epigenetics in tumor initiation, progression, and metastasis. It describes the importance of dietary and environmental factors on cancer epigenetics. It ranges from basic science to landmark discoveries in clinical practice. It highlights diagnostic and prognostic aspects of epigenetics in cancerand advances in gene therapy. It covers emerging aspects, such as RNA epigenetics, chromosomal position effects, epigenomics, and the role of polycomb-group genes in cancer."Cancer Epigenetics" is an indispensable reference for thosewith interests ranging from the basic mechanisms of tumor biology to cancer therapy. Serving as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer, this seminal work answers the call for a thorough and authoritative book that covers the critical and contemporary aspects of this revolutionary field. INDICE: The Role of Epigenetics in Cancer. DNA Hypomethylation in Cancer. DNA Hypermethylation in Oncogenesis. Imprinting Alterations in Tumorigenesis. Proteins that Modulate DNA Methylation Aberrations in Cancer. The Role of DNA Methylation in Cancer Progression. Alterations in Histone Acetylation in Tumorigenesis. Histone Methylation and the Initiation of Cancer. The Role of Sirtuins in Aging and Tumorigenesis. Proteins that Alter Histone Modifications in Cancer. Dietary and Environmental Influences on Histone Modifications in Cancer.Noncoding RNAs in Cancer. Cancer-linked DNA Hyper- and Hypomethylation: Chromosome Positional Effects. Chromatin Remodeling and Cancer. Poly-ADP-ribosylation in Cancer. Polycomb Group Proteins in Tumorigenesis. Cancer and Aging: The Epigenetic Connection. DNA Methylation in Tumor Diagnosis. DNA Methylation Profiles as Prognostic Markers for Cancer. Diagnosing Cancer Using Histone Modification Analysis. Histone Modifications in Cancer Biology and Prognosis. Histone Deacetylase Inhibitors in Cancer Therapy. Methylation Changes in Neoplasia: Diagnostic and Therapeutic Implications. Clinical Trials and Approved Drugs for Epigenetic Cancer Therapy. Future Directions in Epigenetic Cancer Research.
- ISBN: 978-1-4200-4579-6
- Editorial: CRC Press
- Encuadernacion: Cartoné
- Páginas: 446
- Fecha Publicación: 08/09/2008
- Nº Volúmenes: 1
- Idioma: Inglés