Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usageSide-by-side coverage of the basis of epigenetic diseases and their treatmentsEvaluation of recent epigenetic clinical breakthroughs INDICE: Epigenetics of Human Disease Methods and Strategies to Determine Epigenetic Variation in Human Disease DNA Methylation Alterations in Human Cancers Alterations of Histone Modifications in Cancer MicroRNA in Oncogenesis Epigenetic Approaches to Cancer Therapy Epigenomics in Neurobehavioral Diseases Emerging Role of Epigenetics in Human Neurodevelopmental Disorders The Epigenetics of Alzheimer's Disease Epigenetic Modulation of Human Neurobiological Disorders Epigenetic Basis of Autoimmune Disorders in Humans Approaches to Autoimmune Diseases Using Epigenetic Therapy Epigenetic Mechanisms of Human Imprinting Disorders Epigenomic Factors in Human Obesity Epigenetic Approaches to Control Obesity Epigenetics of Diabetes in Humans The Potential of Epigenetic Compounds in Treating Diabetes Epigenetic Aberrations in Human Allergic Diseases, Therapy of Airway Disease: Epigenetic Potential The Role of Epigenetics in Cardiovascular Disease Epigenetics and Human Infectious Diseases The Epigenetics of Endometriosis Aberrant DNA Methylation in Endometrial Cancer Stem Cell Epigenetics and Human Disease Non-Coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy Aging and Disease: The Epigenetic Bridge Early-Life Epigenetic Programming of Human Disease and Aging
- ISBN: 978-0-12-388415-2
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 592
- Fecha Publicación: 14/09/2012
- Nº Volúmenes: 1
- Idioma: Inglés