Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine INDICE: Section A Overview1. Advances in medical epigeneticsSection B General medical aspects of epigenetics2. Environmental epigenetic epidemiology3. Lifestyle and preventive medical epigenetics4. Environmental medical epigenetics: A review of epigenetically induced medical risks generated from exposures in our air, food, and personal products5. Behavioral medical epigenetics6. Medical epigenetics and twins7. Epigenetic biomarkers of disease8. Prognostic epigeneticsSection C Epigenetics of system disorders9. Autoimmune disease and epigenetics10. Epigenetics of pulmonary diseases11. Cardiovascular disorders and epigenetics12. Epigenomics of intestinal disease13. Epigenetics of skin disorders14. Epigenetics in bone and joint disorders15. Epigenetics of muscle disorders16. Reproductive disease epigenetics17. Epigenetics in ocular medicineSection D Multi-system medical epigenetics18. Pediatric diseases and epigenetics19. Epigenetics of infectious diseases20. Clinical utility of solid tumor epigenetics21. Epigenetics in acute myeloid leukemia22. Epigenetic regulation in cancer metastasis23. Epigenetics in exercise science and sports medicineSection E Bioinformatics of epigenetic medicine24. Machine learning in epigenetic diseasesSection F Pharmacology of epigenetics25. Epigenetics in toxicology and drug development26. Pharmacoepigenomics in neurodegenerative diseasesSection G Therapeutic epigenetics27. Therapeutics and DNA methylation inhibitors28. Histone deacetylase inhibitors in medical therapeutics29. Sirtuins as NAD+-dependent deacetylases and their potential in medical therapy30. Experimental approaches toward histone acetyltransferase modulators as therapeutics31. Histone methylation modifiers in medical therapeutics32. Modulation of noncoding RNAs (ncRNAs) and their potential role as therapeutics33. Nutrients and phytonutrients as promising epigenetic nutraceuticals34. Epigenetics of pain management35. Precision medical epigenetics36. Epigenetics and regenerative medicine37. Stem cell epigenetics in medical therapy38. The clinical landscape of HDAC inhibitorsSection H Medical epigenetics: Future prospects39. Epigenetics: Future prospective in human disorders and therapeutics40. Prospective advances in medical epigenetics
- ISBN: 978-0-12-823928-5
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 970
- Fecha Publicación: 26/08/2021
- Nº Volúmenes: 1
- Idioma: Inglés