Ocular transporters in ophthalmic diseases and drug delivery

This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium. Focus on the molecular characteristics, localization, and substrate spevidieis in various compartments of the eye of several classes of well-known membran transporters. Illustrates how mutations or dysfunction of specific transporters can contribute to various disorders in the eye including blindness. Examines how epithelial and endothelial barriers can block drug delivery and limit ocular availibility of drugs. INDICE: From the contents Aquaporins and water transport in the cornea.- Roles of Corneal Epithelial Ion Transport mechanisms in mediating responses to cytokines and osmotic stress.- Vitamin C Transport, Delivery, and Function in the Anterior Segment of the Eye.- Mechanisms of Aqueous Humor Formation: Cellular Model of aqueous inflow.- Membrane Transporters: New Roles in Lens Cataract.- Lens Na+ K-ATPase.- Pathophysiology of Perictye-Containing Retinal Microvessels: Roles of Ion Channels and Transporters.- Molecular mechanisms of the Inner Blood-Retinal Barrier Transporters.- Regulation of Transport in the RPE.- Glucose Transporters in RPE Development.- Ca2+ Channels in the RPE: Modulatorsof RPE Function and Communication with Neighboring Tissues.- Taurine Transport Pathways in the Outer Retina in Relation to Ageing and Disease.- P-glycoprotein expression and Function in the Retinal pigment epithelium.- The Retinal Rod NCKX1 and Cone/Ganglion Cell NCKX2 Na+/Ca2+-K+ Exchangers.

• ISBN: 978-1-58829-958-1
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 464
• Fecha Publicación: 01/03/2008
• Nº Volúmenes: 1
• Idioma: Inglés