Both a reference source for researchers and a text for graduate students investigating the various aspects of the dopamine transporter (DAT), Dopamine Transporter: Chemistry, Biology, and Pharmacology includes aspects of chemistry, biology, and pharmacology and provides a strong general overview of this neurotransmitter. Serving as a much-needed resource for scientists working in the field of drug abuse, in particular treatments for cocaine, the chapters in this text bring together otherwise scattered information under one cover to presentdetails about DAT related to drug design and synthesis, medicinal chemistry, and pharmacology. INDICE: Preface. Chapter 1: The Dopamine Transporter: An Anatomical Perspective (Hilary R. Smith, Thomas J. Beveridge, Colleen A. Hanlon, Linda J. Porrino). Chapter 2: Dopamine Transporter, Disease States and Pathology (Deborah C.Mash). Chapter 3: Cloning and Genetic Analysis of Dopamine Transporters (David J. Vandenbergh). Chapter 4: Molecular Structure and Composition of Dopamine Transporters (M. Laura Parnas and Roxanne A. Vaughan). Chapter 5: Electrochemical characterization of dopamine transporters (Evgeny A. Budygin and Sara R. Jones). Chapter 6: Tropane-based dopamine transporter uptake inhibitors (Scott P. Runyon and F. Ivy Carroll). Chapter 7: The Benztropines: Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine?s Mechanism at the DopamineTransporter (Amy Hauck Newman and Jonathan L. Katz). Chapter 8: SAR of GBR 12909 Ligands (Thomas E. Prisinzano and Kenner C. Rice). Chapter 9: Structure-activity relationship study of piperidine derivatives for dopamine transporters (Prashant S. Kharkar, Maarten E. A. Reith, and Aloke K. Dutta). Chapter 10: Non-nitrogen containing dopamine transporter uptake inhibitors (Peter C. Meltzer). Chapter 11: Dopamine Releasing Agents (Bruce E. Blough). Chapter 12: PET/SPECT Imaging Studies of the Plasma Membrane DAT (Paul Cumming, Weiguo Ye, Dean F. Wong). Chapter 13: In Vitro Studies of Dopamine Transporter Function and Regulation (Brian R. Hoover, Bruce H. Mandt and Nancy R. Zahniser). Chapter 14: In vivo studies of dopamine transporter function (Jane B. Acri).
- ISBN: 978-0-470-11790-3
- Editorial: John Wiley & Sons
- Encuadernacion: Cartoné
- Páginas: 464
- Fecha Publicación: 01/08/2008
- Nº Volúmenes: 1
- Idioma: Inglés