INDICE: Preface. Chapter 1: Introduction (Corinne Kay). Chapter 2: In silico ADME/Tox Predictions (David Lagorce, Christelle Reynes, Anne-Claude Camproux, Maria A. Miteva, Olivier Sperandio, and Bruno O. Villoutreix). Chapter 3: Absorption and Physicochemical Properties of the NCE (Jon Selbo and Po-Chang Chiang). Chapter 4: ADME (Martin E. Dowty, Dean M. Messing, Yurong Lai, and Leonid (Leo) Kirkovsky). Chapter 5: Pharmacokinetics for Medicinal Chemists (Leo Kirkovsky and Anup Zutshi). Chapter 6: Cardiac Toxicity (Ralf Kettenhofen and Silke Schwengberg). Chapter 7: Genetic Toxicity: In Vitro Approaches for Medicinal Chemists (Richard M. Walmsley and David Elder). Chapter 8: Hepatic Toxicity(Jinghai James Xu and Keith Hoffmaster). Chapter 9: In Vivo Toxicological Considerations (John P. Devine, Jr.). Chapter 10: Pre-clinical Candidate Nomination and Development (Nils Bergenhem). Chapter 11: Fragment-Based Drug Design: Considerations for Good ADME Properties (Haitao Ji).
- ISBN: 978-0-470-48407-4
- Editorial: John Wiley & Sons
- Encuadernacion: Cartoné
- Páginas: 516
- Fecha Publicación: 07/01/2011
- Nº Volúmenes: 1
- Idioma: Inglés