CRISPR Genome Surgery in Stem Cells and Disease Tissues: From Discovery to Therapy focuses uniquely on clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases such as: retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The target audience includes researchers, students, clinicians, and the general public; all drawn to the book by its applicability to their research and patients. This is a space that is not currently served by any existing resource like this and the publication fills a gap in current literature. Provides thorough review of CRISPR-Cas9, from discovery to therapyCovers the latest advances in gene editing and its translational applications to various diseasesWritten by global leaders in the fields of gene editing and stem cell therapy INDICE: 1. History of CRISPR 2. Different Kinds of CRISPR (SpCas9, CjCas9, CaCas9, etc.) 3. Genome engineering in iPSC cells 4. CRISPR manipulations in stem cell lines for neurological diseases 5. Gene editing for the cornea 6. CRISPR screening for eye diseases 7. Employing Non-homologous End Joining and Homology-directed Repair for Treatment of Leber Congenital Amaurosis and Retinal Degeneration 8. Ethics of Gene Editing in Human Stem Cells 9. sGRNA 10. CRISPR vs ZFN/TALEN
- ISBN: 978-0-12-817876-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 225
- Fecha Publicación: 03/08/2020
- Nº Volúmenes: 1
- Idioma: Inglés