Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure highlights emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immune, endocrine, genetic and epigenetic effects of long-term exposure as well as examines how combined exposures to nanomaterials, metals, pharmaceuticals, multi-frequency radiation, dietary mycotoxins and pesticides accelerate ecotoxicity on humans, animals, plants and the larger environment. The book also offers insight into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. Current Aspects of Modern Toxicology is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. Bridges basic research with clinical, epidemiological, regulatory and translational research, conveying both an introductory understanding and the latest developments in the fieldEvaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic diseaseDiscusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research INDICE: 1. Toxicogenomics and Pharmacogenomics 2. Health Based exposure limits and toxicological impact on pharmaceutical industry 3. Nanoparticle toxicology: risk assessment and prediction tools (or Advances in Nanotoxicology) 4 Predictive in silico toxicology: An update on modern approaches and a critical analysis of its strong and weak points 5. Hydrogen sulphide: a shifting paradigm 6. Epigenetic mechanisms in nanomaterial toxicity 7. The role of extracellular matrix in contact allergen-mediated keratinocyte activation 8. Integrating immunotoxicology in the modern toxicology strategy 9. Mixture toxicity evaluation in modern toxicology 10. Toxicity of psychedelic drugs 11. Hormesis: A classic dose-response model for modern toxicology 12. Electrophoretic/electrokinetic methods in Forensic and Clinical Toxicology 13. Toxicity of Arsenicals in Diseases: Friend or Foe? 14. Endocrine disruption and human health risk assessment under the light of real life risks and RLRS 15. Analytical strategies to study the role of the gut microbiome in toxicology 16. Alternative methods and their role in modern toxicology 17. Modern Approaches for the Assessment of Human Exposure to Dietary Mycotoxins 18. Toxicants induced gut dysbiosis and increased intestinal permeability 19. Predictive Nanotoxicology: From Nanotoxicity to Nanosafety of Select and Commonly Used Nanomaterials 20. Renal Mitochondria as Sentinels for Exposures to Environmental Toxicants and Nephrotoxic Drugs 21. Recent updates on ecotoxicity effects of Titania nanoparticles in marine systems 22. Integration between Epidemiology & Toxicology in Public Health 23. Redox Biomarkers in Toxicology: a Nutritional Approach 24. The use of toxicology data to establish acute and short term emergency exposure guidance 25. Synthetic cannabinoid-induced psychopathology: current challenges of mechanistic toxicology 26. Chemobrain 27. Immunotoxicity of pesticides: current knowledge and perspectives 28. Nrf2-mediated antioxidant response as an indicator of oxidative stress 29. Phytoconstituents toxicological issues 30. In silico modeling, a robust approach for predicting toxicity in Next Generation Risk Assessment? 31. Current and emerging (broader) concepts of cardiotoxicity 32. The exposome - a new paradigm for non-animal toxicology and integrated risk assessment 33. Metabolomics: Diagnostic and Therapeutic Applications in Clinical Medicine and Pharmacology 34. Metabolomics Methodology and Workflow: Challenges and Future Prospects 35. Dethroning the crown. From the kinetics and dynamics of COVID-19 diagnosis to the promising treatments 36. Evidence of immune-endocrine alteration following glyphosate exposure 37. Challenges of developmental toxicity testing: Toxic imprinting of adult diseases 38. Ciguatera toxins. Toxicity and Food Safety 39. Toxicology aspects of biomaterials 40. Toxicology issues related to COVID-19 outbreak 41. Current findings on biomonitoring and risk assessment of endocrine disruptors 42. Progress in analytical toxicology 43. Neurobehavioral toxicology 44. Marine toxicology 45. Social toxicology 46. Neurotoxicology issues 47. Food toxicology and risk assessment

• ISBN: 978-0-323-85215-9
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 370
• Fecha Publicación: 01/08/2021
• Nº Volúmenes: 1
• Idioma: Inglés