Psychiatric Genomics

Although psychiatric disorders affect a large percentage of the world population, current treatment approaches and drugs administered often come with unwelcome side effects that may decrease patients' quality of life. Psychiatric genomics is a rapidly growing field that adopts computational approaches to identify genetic factors underlying psychiatric disorders, as well as the appropriate drug and dosage plans, to enhance personalized treatment and avoid adverse reactions. Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, and offers methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, across 23 chapters, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues. Methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research. Thoroughly examines genetic mechanisms underlying a broad range of psychiatric disordersOffers genomic methodologies and analytical approaches supporting new research and clinical translation, as well as personalized diagnosis and treatment modelsFeatures chapters contributions from international leaders in the field INDICE: 1. Genomics and psychiatry: A historical overview 2. Genetics of schizophrenia 3. Genetics of bipolar disorder 4. Genetics of depression 5. Genetics of personality disorders 6. Genetics of anxiety disorders 7. Genetics of addictions 8. Genetics of eating disorders 9. Genetics of sleep disorders 10. Nutrition, genomics and psychiatric disorders 11. Pharmacogenomics and antipsychotics: Efficacy and adverse drug reactions 12. Pharmacogenomics and antidepressants: Efficacy and adverse drug reactions 13. Pharmacogenomics and mood stabilizers: Efficacy and adverse drug reactions 14. Implementing pharmacogenomics into the psychiatric clinic 15. Ethical issues in applying psychiatric genomics and pharmacogenomics 16. Animal models of psychiatric genomics 17. Methodologies and analytic approaches 18. Brain pathophysiology and genetic factors 19. Integration with systems biology approaches and omics data to characterize risk variation 20. Usage of biobank data for psychiatric genomics and promotion of precision psychiatry 21. Shared heritability among traits 22. Endophenotypes in the field of psychiatric genomics

• ISBN: 978-0-12-819602-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 424
• Fecha Publicación: 01/11/2020
• Nº Volúmenes: 1
• Idioma: Inglés