Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more. Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided Includes contributions from recognized experts in the field INDICE: 1. Intrinsic disorder and phase transitions: Pieces in the puzzling role of the prion protein in health and disease Mariana J. do Amaral and Yraima Cordeiro 2. Functions of intrinsically disordered proteins through evolutionary lenses Mátyás Pajkos and Zsuzsanna Dosztányi 3. Non-specific porins of Gram-negative bacteria as proteins containing intrinsically disordered regions with amyloidogenic potential Olga D. Novikova, Vladimir N. Uversky and Elena A. Zelepuga 4. Intrinsic disorder in integral membrane proteins Brian J. Aneskievich, Rambon Shamilov and Olga Vinogradova 5. Molecular simulations of IDPs: From ensemble generation to IDP interactions leading to disorder-to-order transitions Hebah Fatafta, Suman Samantray, Abdallah Sayyed-Ahmad, Orkid Coskuner-Weber and Birgit Strodel 6. Target-binding behavior of IDPs via pre-structured motifs Do-Hyoung Kim and Kyou-Hoon Han 7. The role of dancing duplexes in biology and disease Heather M. Forsythe and Elisar Barbar 8. Intrinsic disorder in protein kinase A anchoring proteins signaling complexes Mateusz Dyla and Magnus Kjaergaard 9. Protein intrinsic disorder on a dynamic nucleosomal landscape Sveinn Bjarnason, Sarah F. Ruidiaz, Jordan McIvor, Davide Mercadante and Pétur O. Heidarsson 10. Flexible spandrels of the global plant virome: Proteomic-wide evolutionary patterns of structural intrinsic protein disorder elucidate modulation at the functional virus-host interplay Rachid Tahzima, Annelies Haegeman, Sébastien Massart and Eugénie Hébrard

• ISBN: 978-0-323-85299-9
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 434
• Fecha Publicación: 19/10/2021
• Nº Volúmenes: 1
• Idioma: Inglés