Pedigree Analysis in R covers a wide range of applications in forensic and medical genetics. The book's material was developed through teaching numerous courses on genetic relatedness and pedigree analysis and includes extensive use of R and insights from a decade of research activities in forensic and medical genetics. The Ped Suite, a unified collection of R packages for pedigree analysis, will help users navigate the book's contents. Presents a coherent treatment of a variety of pedigree analysesTreats a variety of pedigree analysis, including theoretical backgrounds, an overview of R features/analysis, an in-depth analysis of a worked examples, exercises, and easy-to-follow R code with explanations INDICE: 1. Introduction Basic applications 2. Creating, manipulating and plotting pedigrees in R [pedtools] 3. Coefficients of relatedness [ribd] 4. Pedigree likelihoods and genotype probabilities [pedprobr] Forensic applications 5. Relationship inference [forrel] 6. Power analysis for kinship testing [forrel] 7. Identification of missing grandchildren [forrel] Medical applications 8. Medical linkage analysis [paramlink2] 9. Segregation analysis for evaluating variant pathogenicity [segregatr] Simulation techniques 10. Conditional and unconditional simulation of dna profiles [forrel] 11. Simulation of identity-by-descent patterns [ibdsim2] Bonus chapter 12. Pedigree reconstruction [pedbuildr]
- ISBN: 978-0-12-824430-2
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 150
- Fecha Publicación: 01/03/2021
- Nº Volúmenes: 1
- Idioma: Inglés