Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studiesOffers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human healthFeatures chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms INDICE: Introduction to human genetics Stankiewicz, Lupski, Tekin 1. Modelling candidate genes vs genetic variants Walz, Young 2. Disease in a dish: Cellular models to understand human conditions Walz, Goldstein 3. The Yeast, a versatile model system to study human disease Lundblad 4. The worm, how can it help? K. A. Caldwell; G.A. Caldwell 5. Understanding human genetic disease with the fly Reiter 6. The fish as a model for human diseases Badano; Katsantis 7. The mouse model Young, Walz 8. Large animal models of rare genetic disorders Eccles; Sasaki 9. Crisper/Cas technology Gurumurthy 10. Integrative modeling and novel technologies in human genomics Young
- ISBN: 978-0-12-816573-7
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 312
- Fecha Publicación: 01/08/2019
- Nº Volúmenes: 1
- Idioma: Inglés