Polyphenols: Mechanisms of Action in Human Health and Disease

Polyphenols are a unique group of phytochemicals that are present in all fruits, vegetables, and other plant products. They are a very diverse and multi-functional group of active plant compounds with powerful antioxidant properties. They exhibit remarkable chemical, biological and physiological properties, including antioxidant, cancer prevention, and cardio-protective activities. Mechanisms of Action of Polyphenols in Human Health and Disease, Second Edition, describes the mechanisms of polyphenol antioxidant activities and their use in disease prevention. Chapters highlight the anti-inflammatory activity of polyphenols on key dendritic cells, how they modulate and suppress inflammation, and how they are inactivated or activated by metabolism in the gut and circulating blood. Polyphenols have proven effective for key health benefits, including bone health, organ health, cardiac and vascular conditions, absorption and metabolism, and cancer and diseases of the immune system. Expands coverage on green tea, cocoa, wine, cumin and herbsOutlines chemical properties, bioavailability and metabolomics of polyphenols to understand their antioxidant mechanismsProvides a self-teaching guide to learn the mechanisms of action and health benefits of polyphenols INDICE: VOLUME 1 OVERVIEW OF POLYPHENOLS AND HEALTH 1. Polyphenols in Foods and Dietary Supplements: Role in Veterinary Medicine and Animal Health 2. Polyphenols and Public Health 3. The History of Islamic Medicine at a Glance 4. Polyphenols and Their Formulations: Different Strategies to Overcome the Drawbacks Associated with Their Poor Stability and Bioavailability 5. Biological Activities of Polyphenols from Grapes 6. The Atomic Level Interaction of Polyphenols with the A? Oligomer Aggregate: A Molecular Dynamic Guidance for Rational Drug Design 7. Polyphenols as Supplements in Foods and Beverages: Recent Methods, Benefits and Risks BIOAVAILABILITY - possible new section 8. Using Recombinant Microorganisms for the Synthesis and Modification of Flavonoids and Stilbenes 9. Bioavailability of Flavonoids: The Role of Cell Membrane Transporters 10. Microorganism Metabolic Activity Stimulation by Polyphenols 11. Interaction of Polyphenols with the Intestinal and Placental Absorption of some Nutrients and other Compounds 12. Bioavailability and Metabolism of Citrus Fruit Beverage Flavanones in Humans 13. Uptake and Metabolism of Dietary Proanthocyanidins 14. Bioavailability of Dietary Anthocyanins and Hydroxycinnamic Acids 15. Microbial Metabolism of Polyphenols and Health 16. The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability: An Overview OXIDATION AND ANTIOXIDANT ACTIVITY OF POLYPHENOLS 17. Implications of Polyphenols on Endogenous Antioxidant Defense Systems in Human Diseases 18. Potent Antioxidant and Anti-Inflammatory Flavonoids in the Nutrient-Rich Amazonian Palm Fruit, Ac¸a´i (Euterpe spp.) 19. Dark Chocolate/Cocoa Polyphenols and Oxidative Stress 20. Polyphenol Antioxidants from Natural Sources and Contribution to Health Promotion 21. Antioxidant Role of Catechin in Health and Disease 22. Cytoprotective Effects of Polyphenols against Oxidative Damage 23. The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress 24. Polyphenols and Low Iron Bioavailability 25. Galloylation and Polymerization: Role of Structure to Antioxidant Activity of Polyphenols in Lipid Systems 26. Chemical Properties, Bioavailability, and Metabolomics of Fruit Proanthocyanidins POLYPHENOLS IN THERAPY OF OBESITY AND DIABETES 27. Anthocyanins and Diabetes Regulation 28. Influence of Dietary Polyphenols on Carbohydrate Metabolism 29. Polyphenols in Ayurvedic Medicine and Type 2 Diabetes 30. Antidiabetic and Anticancer Potential of Native Medicinal Plants from Saudi Arabia 31. Prevention of Diet-Induced Obesity by Dietary Polyphenols Derived from Nelumbo nucifera and Black Tea 32. Antidiabetic, Antihyperlipidemic and Antioxidant Effects of the Flavonoids 33. Dietary Quercetin and other Polyphenols: Attenuation of Obesity 34. Role of Protocatechuic Acid in Obesity-Related Pathologies 35. Food and Supplement Polyphenol Action in Cancer Recurrence 36. Polyphenols from Pongamia pinnata (Linn.) Pierre in Metabolic Disorder 37. Garlic (Allium sativum): Role in Metabolic Disorder 38. Polyphenols and Flavonoids in Controlling Non-Alcoholic Steatohepatitis 39. Modulation of Intestinal Cholesterol Absorption by Dietary Tea Polyphenols POLYPHENOLS IN BRAIN AND NEUROBIOLOGY HEALTH 40. Plant Polyphenols as Dietary Modulators of Brain Functions 41. Anti-Inflammatory Activity of Polyphenols on Dendritic Cells 42. Polyphenols Suppress and Modulate Inflammation: Possible Roles in Health and Disease 43. Anti-Inflammatory Properties of Cinnamon Polyphenols and their Monomeric Precursors 44. Polyphenols in the Prevention of Acute Pancreatitis: Preclinical Observations 45. Anti-Inflammatory and Immunomodulatory Properties of Dietary Flavonoids 46. Immunomodulatory Ethnobotanicals of the Great Lakes 47. Pongamia pinnata (Linn.) Pierre and Inflammation 48. Polyphenol-Mediated Beneficial Effects in Healthy Status and Disease with Special Reference to Immune-Based Mechanisms DIVERSE DISEASE AND PHYSIOLOGICAL STATES MODIFIED BY POLYPHENOLS 49. Polyphenols and Skin Cancers 50. Polyphenols in the Prevention of Ulcerative Colitis 51. Protection and Reversal of Hepatic Fibrosis by Polyphenols 52. Hepatoprotective Effects of Green Tea and its Polyphenols 53. Green Tea and other Fruit Polyphenols Attenuate Deterioration of Bone Microarchitecture 54. Polyphenolics Evoke Healing Responses 55. Polyphenols and Reproductive Health 56. Polyphenols and Tuberculosis 57. Protection by Polyphenols Against Mitochondrial Damage and Cytotoxicity 58. Safety of High and Long-term Intake of Polyphenols 59. Polyphenols in Health and Disease 60. Curcumin/Turmeric as an Environment-friendly Stain for Proteins on Acrylamide Gels 61. Turmeric and its Principle Compound Curcumin are Effective in the Prevention and Treatment of Arthritis 62. Polyphenols and Skin Cancers 63. Polyphenols and Polyphenol-Derived Compounds and Contact Dermatitis 64. Polyphenols against Skin Aging 65. Skin Photoprotection by Polyphenols in Animal Models and Humans 66. Polyphenols Nano-Formulations for Topical Delivery and Skin Tissue Engineering 67. Studying Tea Polyphenols and Their Protective Effects on Skin 68. Polyphenols: A Remedy for Skin Wrinkles

• ISBN: 978-0-12-813006-3
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 512
• Fecha Publicación: 01/09/2018
• Nº Volúmenes: 1
• Idioma: Inglés