The kinetochore: from molecular discoveries to cancer therapy

Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, butkinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. ‘The Kinetochore: from Molecular Discoveries to Cancer Therapy’ presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and ‘model’ eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as avery rich target for the next generations of anti-cancer drugs. Ties togetherthe latest research into the workings of the kinetochore/centromere complex and neocentromeres; including what is known about their structure, how they function, how they are regulated, their involvement in the etiology of cancer, and how these structures might be targeted in cancer therapeutics INDICE: Foreword.- The kinetochore and centromere: a historical perspective.- The mitotic and meiotic chromosome cycles in eukaryotes.- The centromere and neocentromere.- Human artificial centromeres.- Architectural and functionalorganization of kinetochores.- Holokinetochores.- Evolution of centromeres and kinetochores.- Structural and functional analysis of the spindle.- Kinetochore-spindle attachment.- Regulation of kinetochore activity.- Epigenetic regulation of kinetochore activity.- Regulation of spindle assembly checkpoint activity at the kinetochore.- Role of the kinetochore in meiosis.- The kinetochore cancer connection.- Kinetochore mutations in cancer tissues.- The kinetochore as an anti-cancer target.

• ISBN: 978-0-387-69073-5
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 430
• Fecha Publicación: 01/12/2008
• Nº Volúmenes: 1
• Idioma: Inglés