MicroRNA: From Bench to Bedside provides an in-depth, expansive overview of microRNA from fundamentals to clinical practice. It presents researchers with detailed insights on the topic of microRNA, exploring foundational knowledge that is followed by methodologies and the latest technologies for research and potential theragnostic and therapeutic applications for specific diseases. The book consists of eight parts, beginning with an introduction to microRNA and the current state of the field, followed by sections on biogenesis and maturation of microRNA, and methodology and bioinformatics, where chapters focus on isolation and detection techniques. Sections then move on to molecular mechanisms and gene regulation, considering topics such as transcriptional regulation and epigenetic regulation, as well as the role of microRNA as biomarkers. Additionally, microRNA and human disease and microRNA-based therapeutics are explored, focusing on a wide range of diseases such as cancer, age-related disease, cardiovascular disease, microRNA targeted therapy in hepatitis and therapeutic strategies for diabetes. The book concludes with a discussion on advances and future perspectives in microRNA investigation. Covers the topic of microRNA in detail, from foundational knowledge to clinical application Explores the physiological and pathological roles of microRNAs in various human diseases, including neurological, cardiovascular and age-related diseases Discusses future directions and challenges in the field Includes chapters on methodology and bioinformatics for microRNA research INDICE: Part I: Overview1. An overview of microRNAsPart II: Methodology and Bioinformatics2. MicroRNA isolation3. Detection of microRNA4. MicroRNA Interference5. Target prediction and validation of microRNA6. Online databases for microRNA ResearchPart III: Biogenesis and Maturation7. Biogenesis of microRNAs8. Molecular basis for microRNA processing9. Maturation of microRNAsPart IV: Molecular Mechanisms and gene regulation10. Function microRNA in cytoplasm11. Mechanisms of miRNA Nuclear Localization12. MiRNA-Mediated Transcriptional Regulation13. Epigenetic Regulation and microRNA Expression14. RNA m6A modification and microRNAsPart V: MicroRNA as biomarkers15. Detection Methodologies for microRNA biomarker profiling16. Circulating microRNAs17. MicroRNA Profiling of Exosomes18. MicroRNAs and biomarkersPart VI: MicroRNAs and human diseases19. MicroRNAs and Cancers20. MicroRNAs and the Immune System21. MicroRNAs in Cardiovascular Diseases22. MicroRNAs in aging and age-related Diseases23. MicroRNAs in Neurological Diseases24. MicroRNAs in Muscle Atrophy25. MicroRNAs in Respiratory Diseases26. MicroRNAs in Liver DiseasesPart VII: MicroRNA Based Therapeutics27. Overview of MicroRNA Based Therapeutics28. MicroRNA Based Therapeutic Strategies for Cancer29. MicroRNA Targeted Therapy in Cardiovascular disease30. MicroRNA Targeted Therapy in Hepatitis31. MicroRNA Based Therapeutic Strategies for Diabetes32. Clinical studies involving microRNAsPart VIII: Concluding Perspectives33. Prospective advances in microRNAs investigation
- ISBN: 978-0-323-89774-7
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 500
- Fecha Publicación: 01/08/2022
- Nº Volúmenes: 1
- Idioma: Inglés