Systems biology in drug discovery and development: methods and protocols

Due to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the technologies can be applied in science for disease understanding and therapeutic discovery. As a volume in the highly successful Methods in Molecular Biology™ series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and up-to-date, Systems Biologyin Drug Discovery and Development: Methods and Protocols covers topics from fundamental concepts to advanced technologies in order to best serve biomedicalstudents and professionals at all levels who are interested in vital integrative studies in molecular biology, genetics, bioinformatics, bioengineering, biochemistry, physiology, pathology, microbiology, immunology, pharmacology, toxicology, drug discovery, and clinical medicine. Focuses on translational methods through applying systems biology approaches directly in drug development and clinical practice Aims toward the goal of truly personalized medicine Features expert tips from successful labs from around the world INDICE: Proteomics and Systems Biology: Application in Drug Discovery and Development.- Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-Target Drugs.- Systems Biology “On-the-Fly”: SILAC-Based Quantitative Proteomics and RNAi Approach in D. Melanogaster.- Systems Biology of Cell Behaviour.- Computational Modeling in Systems Biology.- An Introduction to Gaussian Bayesian Networks.- Derivation of Large-Scale Cellular Regulatory Networks from Biological Time Series Data.- Translational Bioinformatics and SystemsBiology Approaches for Personalized Medicine.- Systems Biology and Inflammation.- Immunoinformatics and Systems Biology Methods for Personalized Medicine.-Systems Biology Approaches to the Study of Cardiovascular Drugs.- Cancer Systems Biology.- Systemic Lupus Erythematosus: From Genes to Organ Damage.- Systems Biology of Influenza: Understanding Multi-Dimensional Interactions for Personalized Prevention and Treatment.- Methods in Systems Biology of ExperimentalMethamphetamine Drug Abuse.- Systems Biology and Theranostic Approach to DrugDiscovery and Development to Treat Traumatic Brain Injury.

• ISBN: 978-1-60761-799-0
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 325
• Fecha Publicación: 29/08/2010
• Nº Volúmenes: 1
• Idioma: Inglés