Epigenetics of Stress and Stress Disorders, a new volume in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA following prolonged stress or trauma. This is accomplished through the evaluation of both the physiological and molecular effects of stress on the body that can eventually lead to stress disorders. The book begins by providing a psychiatric, biological, and phenomenological foundation for understanding stress disorders, before delving into the genomics of stress disorders. From here, chapter authors discuss a range of recent epigenetic research in the area, highlighting epigenome-wide association studies (EWAS), exciting developments in noncoding RNA studies, possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PTSD on the health of patients. The book also examines the effect of adversity during sensitive periods or development and across the life span. The book concludes by looking at possible transgenerational stress-induced epigenetic alterations on future offspring and important areas of research for public health, along with the potential for epigenetic therapeutics or epidrugs.? Examines the epigenetics of stress, trauma, and related stress disorders Connects new research to clinical practice and highlights implications for patient care, drug discovery, and public health Discusses the epigenetic effect of adversity across the life span, and transgenerational stress-induced epigenetic alterations Features chapter contributions from international experts in the field INDICE: 1. The physiology of stress and the human body's response to stress 2. Posttraumatic stress disorder: Diagnosis, measurement, and assessment 3 .Nikola Tesla: An autobiographical case study of trauma and resilience 4. Management of posttraumatic stress disorder 5. Depression and epigenetics: Epidemiology, pathophysiology, diagnosis, and assessment 6. Depression management and pharmacoepigenetics 7. Psychotherapy for stress disorders: A military perspective 8. How stress affects gene expression through epigenetic modifications 9. Proposed effect of epigenetic alterations on stress-related disorders 10. PTSD and physiology: The long-term effects of PTSD and relation to epigenetics, physical health, and chronic diseases 11. Epigenomic biomarkers of posttraumatic stress disorder 12. Adversity across time: Do sensitive periods across the life span determine adversity-induced epigenetic changes? 13. PTSD, telomeres, and aging 14. Accelerated aging in mood disorders 15. Epigenetics, stress, and depression 16. Capturing the epigenome: Differences among blood, saliva, and brain samples 17. Posttraumatic stress disorder, major depressive disorder, and noncoding RNAs 18. MicroRNAs in posttraumatic stress disorder 19. Potential transgenerational epigenetic effects of prolonged stress and psychological trauma 20. Targeting epigenetics as future treatments of trauma- and stress-or-related disorders. Epidrugs and epinutraceuticals
- ISBN: 978-0-12-823039-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 420
- Fecha Publicación: 18/02/2022
- Nº Volúmenes: 1
- Idioma: Inglés