Through the revolutionary concept of cancer stem cells, cancer research has been reinvigorated to study the role of these unique cells in cancer propagation and as targets of innovative therapies. In Cancer Stem Cells: Methods and Protocols, preeminent researchers have compiled cancer stem cell research techniques and protocols to promote healthy competition, discourse, and collaboration in this vital field. The volume covers extensive topics such as identification and isolation of cancer stem cells, animal models of cancer stem cells, methylation profiling, the contribution of the niche in the regulation of cancer stem cells, immunologic targeting, and the use of normal stem cells as a treatment, among other subjects. Provides easy to follow protocols in this technically challenging field Presents a cohesive review of a variety of methods to isolate, identify, and study cancer stem cells Is a timely contribution in this nascent field and will level the playing field of investigators of cancer stemcells Presents a comprehensive, step-by-step guide by leading researchers in the field of cancer stem cells INDICE: From the contents Defining Cancer Stem Cells by Xenotransplantation in Zebrafish.- Analysis of Cancer Stem Cell Metastasis in Xenograft Animal Models.- Identification of Murine and Human Acute Myeloid Leukemia Stem Cells.-Methods for Analysis of Brain Tumor Stem Cell and Neural Stem Cell Self-Renewal.- Prospective Identification of Cancer Stem Cells with the Surface Antigen CD133.- Neurosphere Culture and Human Organotypic Model to Evaluate Brain Tumor Stem Cells.- Methodologies in Assaying Prostate Cancer Stem Cells.- Characterization of Non-Malignant and Malignant Prostatic Stem/Progenitor Cells by Hoechst Side Population Method.- Anchorage Independent Growth of Prostate Cancer Stem Cells.- Identification of Human Pancreatic Cancer Stem Cells.- Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma.- Pituitary Adenoma Stem Cells.
- ISBN: 978-1-58829-938-3
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 275
- Fecha Publicación: 01/08/2009
- Nº Volúmenes: 1
- Idioma: Inglés