In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called 'protease web', and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events. Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field INDICE: 1. Proteolytic signalling: an introduction André Zelanis, Uilla Barcick and Maurício F. Camacho 2. Ubiquitin-ligases: proteolytic signaling, protein turnover, and disease Felipe Roberti Teixeira, Patricia Passos, Camila Correia, Caio Almeida, Valentine Spagnol and Isabela Fernanda Morales Martins 3. Lysosomal proteases and their role in signaling pathways Rebecca A.B. Burton, Samuel Bose and Thamali Ayagama 4. Antigen processing and presentation through MHC molecules Niels Olsen Saraiva Câmara, Tamisa Honda and Barbara Padovani 5. Proteolytic processing in autophagy João Agostinho Machado-Neto and Andrei Leitão 6. Proteolysis in inflammatory diseases Antoine Dufour and Luiz de Almeida 7. Proteolytic processing of laminin and the role of cryptides in tumoral biology Vanessa Morais Freitas, Ruy Gastaldoni Jaeger and Adriane Sousa de Siqueira 8. Proteolytic signaling in wound healing Ulrich auf dem Keller, Konstantinos Kalogeropoulos and Louise Bundgaard 9. Proteinases disbalance in oral cancer and other diseases Adriana Franco Paes Leme 10. 'Omics' approaches for investigating protease degradomes in complex biological matrices Pitter F. Huesgen and Maithreyan Kuppusamy 11. Protease web Nikolaus Fortelny and Wolfgang Esser-Skala 12. The puzzle of proteolytic effects in hemorrhage induced by Viperidae snake venom metalloproteinases Milene Menezes, Dilza Trevisan-Silva, Daniela Cajado De Oliveira Souza Carvalho and Jessica de Alcantara Ferreira
- ISBN: 978-0-323-85696-6
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 308
- Fecha Publicación: 14/10/2021
- Nº Volúmenes: 1
- Idioma: Inglés