ADME-enabling technologies in drug design and development

This book comprehensively covers the state-of-the-art and cutting-edge technologies in an integrated fashion for applications in ADME studies of small molecular drugs. Each chapter provides descriptions of the technologies, application scope and limitations, optimal conditions for intended results, protocols, case studies, and future developments. By concisely describing these technologies, the book provides a useful tool for drug metabolism scientists and as a reference for scientists in the fields of pharmacology, medicinal chemistry, pharmaceutics, toxicology, bioanalytical science in academia and industry. INDICE: PrefaceDongle Zhang and Sekhar SurapaneniForwardLisa A ShipleyPartA. ADME: Overview and Current Topics1.Regulatory drug disposition and NDA package including MISTSekhar Surapaneni2. Optimal ADME properties of a clinical candidate and investigational new drug (IND) packageRajinder Bhardwaj and Gamini Chandrasena3. Drug transporters in Drug interactions and dispositionImad Hanna and Ryan Pelis4. Pharmacological and toxicological activity of drug metabolitesW. Griffith Humphreys5. Improving the pharmaceutical properties of biologics in drug discovery: Unique challenges and enabling solutionsJiwen Chen and Ashok Dongre6. Clinical dose estimation using pharmacokinetic/pharmacodynamic simulation and modelingLingling Guan7. Pharmacogenomics and individualized medicinesAnthony Lu and Qiang Ma8. Overview of pharmacokinetic and drug metabolismwith applications to drug discovery and development in ChinaChangxiao LiuPartB. ADMET Systems and Methods9. Technical challenges and recent advances of implementing comprehensive ADMET tools in drug discovery and developmentJianlingWang and Leslie Bell10. Permeability and Transporter models in drug discoveryand developmentPraveen Balimane, Yonghae Han, Saeho Chang11. Methods to assess blood brain penetration in drug discoveryDi Li and Edwards H. Kerns12. Protein binding determination and applicationTom Lloyd13. Reaction phenotypingChun Li and Nataraj Kalyanaramn14. Fast and reliable CYP inhibition assaysMing Yao,Hong Cai, and Mingshe Zhu15. Tools and strategies for the assessment of enzyme induction in drug discovery and developmentAdrian J. Fretland, Anshul Gupta,Peijuan Zhu, Catherine L. Booth-Genthe16. Animal models for studying metabolizing enzymes and transportersKevin L. Salyers and Xu Yang17. Milk excretion and placenta studiesMatt Hoffman and Adam Schilling18. Bile collection from animals and humansSuresh Balani, Lisa Christopher, and Donglu ZhangPart C Analytical Technologies19. Current technology and limitation of LC/MSCornelis Hop20. Applications of accurate mass in metabolite identificationZhoupeng Zhang and Kausick Mitra21. Applications of accelerated mass spectrometryXiaomin Wang, VoonOng, and Mark Seymour22. Radioactivity profilingWing Wah Lam, Jose Silva, Lining Cai, and Heng-Keang Lim23. Small scale NMR analysis for metabolite identificationKim a Johnson, Stella Huang, and Yuezhong Shu24. Super-critical fluid chromatography for compound isolationJun Dai, Yingru Zhang, David B. Wang-Iverson, AdrienneTymiak25. Chromatographic separation methodsWenying Jian, Richard W. Edom, Zhongping (John) Lin, and Naidong Weng26. Mass spectrometric imaging for drug distribution in tissuesDaniel P. Magparangalan, Timothy J. Garrett, Dieter M. Drexler, Richard A. Yost27. QWBA applications in drug distributionLifei Wang, Haizheng Hong, and Donglu ZhangPart D. New and Related Technologies28. Genetically modified mouse models in ADME studiesXiling Jiang and Aiming Yu29. Pluripotent stem cells have an important role in human drug developmentDavid Hay30. Radiosynthesis for ADME studiesBrad Maxwell and Chad Elmore31. Formulation development for preclinical in-vivo studiesYuan-Hon Kiang, Darren Reid, and Janan Jona32. In vitro testing of cardiovascular toxicityJiesheng Kang andHaoyu Zeng33. Target engagement for PK-PD modeling and translational biomarkersVanessa N. Barth, Elizabeth M. Joshi, Matt Silva34. Applications of siRNA technologies in drug transporters and drug metabolizing enzymesMingxiang Liao and Cindy XiaÂ

• ISBN: 978-0-470-54278-1
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 622
• Fecha Publicación: 11/05/2012
• Nº Volúmenes: 1
• Idioma: Inglés