Green Techniques for Organic Synthesis and Medicinal Chemistry

An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry.   The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry. INDICE: List of contributors .Foreword .Preface .PART I General Topics in Green Chemistry .1. Green Chemistry MetricsFrank Roschangar and Juan Colberg  .2. Green SolventsJanet Scott and Helen Sneddon  .3. Green Analytical ChemistryPaul Ferguson and Douglas Raynie .4. Green Engineering Christopher L. Kitchens and Lindsay Soh .5. Greening of Consumer Cleaning ProductsDavid C. Long .6. Innovation with Non–Covalent Derivatization John Warner and Emily Stoler .PART II   GREEN CATALYSIS .7.  Catalytic C–H Bond Cleavage for Heterocyclic CompoundsZhanxiang Liu and Yuhong Zhang  .8.  Biocatalysis and Green ChemistryJames Lalonde .9. Practical Asymmetric OrganocatalysisWen–Zhao Zhang, Samik Nanda and Sanzhong Luo .10. Fluorous CatalysisLászló T. Mika and István T. Horváth .11. Solid–supported catalysisSukanta Bhattacharyya and Basudeb Basu .12. Asymmetric Organocatalysis in Aqueous MediaKartick C. Bhowmick and Tanmoy Chanda .PART III   GREEN SYNTHETIC TECHNIQUES .13. Solvent–Free SynthesisKendra Leahy and James Mack .14. Ultrasonic ReactionsRodrigo Cella and Helio A. Stefani  .15. Photochemical SynthesisStefano Protti, Maurizio Fagnoni and Angelo Albini .16. Pot–economy SynthesisWenbin Yi .17. Microwave–Assisted Organic Synthesis: Overview of Recent ApplicationsNandini Sharma, Upendra K. Sharma and Erik Van der Eycken .18. Solid–Supported SynthesisIndrajeet J. Barve and Chung–Ming Sun .19.  Fluorous SynthesisWei Zhang .PART IV   GREEN TECHNIQUES AND STRATEGIES IN THE PHARMACEUTICAL INDUSTRY .20. Ionic Liquids in the Pharmaceutical IndustryJulia L. Shamshina, Paula Berton, Hui Wang, Xiaosi Zhou, Gabriela Gurau and Robin D. Rogers .21. Green Technologies and Approaches in the Manufacture of BiologicsSa V. Ho and Kristi Budzinski .22. Benchmarking Green Chemistry Adoption by Big Pharma and Generics ManufacturersVesela Veleva and Berkeley W. Cue .23. Green Process Chemistry in the Pharmaceutical Industry:  Case Studies Update (2012–2016)Joseph M. D. Fortunak, Ji Zhang, Frederick E. Nytko III and Tiffany N. Ellison .24. Greener Pharmaceutical Science Through Collaboration: The ACS GCI Pharmaceutical RoundtableJulie B. Manley and Michael E. Kopach .Index

• ISBN: 978-1-119-28816-9
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 728
• Fecha Publicación: 16/03/2018
• Nº Volúmenes: 1
• Idioma: Inglés