Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. Discusses technologies that are critical for epigenetic research and applicationIncludes epigenetic applications for state-of-the-art technologiesContains a global perspective on the future of epigenetics INDICE: 1. Introduction of the epigenetic technologies 2. Current Technologies for Genome-wide Mapping of Genomic 5-methylcytosine and 5-hydroxymethylcytosine 3. Technologies to map DNA 5hC and 5fC and 5caC 4. Application of mass spectrometry in translational epigenetics 5. Techniques analyzing chromatin modifications at specific single loci 6. Genetic models for studying critical histone modifications 7. Crystallography-based Mechanistic Insights into Epigenetic Regulation 8. The genetic and chemical approach for targeting site-specific histone modification marks 9. Peptide microarrays for profiling of epigenetic targets 10. Current Methods for Methylome Profiling 11. Bioinformatics and biostatistics for mining epigenetic disease markers and targets 12. Computational modeling to elucidate molecular mechanisms of epigenetic memory 13. DNA methyltransferase inhibitors for cancer therapy 14. Histone acetyltransferase inhibitors and epigenetic applications 15. Histone deacetylase assays and inhibitors 16. Enzymatic assays of histone methyltransferase enzymes 17. Histone methyltransferase inhibitors for cancer therapy 18. Histone demethylases: Targets, Strategies and Inhibitors 19. Fluorescent technologies in studying dynamics of histone modification 20. Animal model study of epigenetic inhibitors
- ISBN: 978-0-12-801080-8
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 484
- Fecha Publicación: 01/07/2015
- Nº Volúmenes: 1
- Idioma: Inglés