Cellular Signalling in Cancer Metastasis provides the reader with in-depth information on the cellular signaling mechanisms responsible for cancer metastasis. While significant progress has been made in understanding the mechanisms responsible for metastasis, the lack of a comprehensive book compiling these aspects was necessary, hence the development of this timely resource. This book is intended to help entry level researchers, from graduate students, postdocs and early career scientists, but is detailed enough to be considered by seasoned scientists. It provides the reader with the current knowledge available on the subject and stimulates others to take up investigations on understanding cancer metastasis. Provides readers with in-depth information on the cellular signaling mechanisms responsible for cancer metastasisExplains the signaling pathways associated with metastasis, ranging from clinical management of metastatic disease, to a systems biology approachBrings together the current knowledge on signaling pathways and the mechanisms responsible for the induction and progression of metastasis, along with present therapeutic options and challenges INDICE: 1. Clinical standpoint of cancer metastasis 2. Motility and tumor invasion in metastasis 3. Epithelial and mesenchymal states and their role in cancer metastasis signalling 4. Hypoxia-induced cancer metastasis signalling 5. Integrins in cancer metastases 6. miRNA mediated regulation of cancer metastasis 7. The Role of Myeloid-Derived Suppressor Cells in Cancer Progression 8. Modulation of endothelial cells for cancer metastasis 9. Vascular endothelial growth factor signalling in cancer metastasis 10. Wnt signalling in cancer metastasis 11. Notch signalling in cancer metastasis 12. GLI signalling in cancer metastasis 13. Mutant TP53 in cancer metastasis 14. CXCR4/CXCL12 in cancer metastasis 15. Role of tumor microenvironment in melanoma metastasis 16. Cancer secretome in cancer metastasis 17. Systems biology of cancer metastasis 18. Systems biology of metabolism in cancer metastasis
- ISBN: 978-0-12-814193-9
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 300
- Fecha Publicación: 01/08/2019
- Nº Volúmenes: 1
- Idioma: Inglés