The Molecular Nutrition of Fats: An Analysis of Implications on Cells to Public Health presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. A part of the Molecular Nutrition series, this book is divided into three sections: general and introductory aspects, molecular biology of the cell, and genetic machinery and its function. The first section, general and introductory aspects, presents coverage in relation to nomenclature, classes and function, lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, levels in the blood, fat-soluble vitamins, lipid emulsions, cancer risk, essential fatty acid deficiency, cardiovascular disease, dementia, intestinal disease, hepatic steatosis, respiratory dysfunction, lipid peroxidation, lipids in emulsions, sterols, stanols and statins. Life stages, including pregnancy and lactation, and public health issues are also discussed. The second section, molecular biology of the cell, includes material on the mitochondria, lipid rafts, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signalling, ligands, G protein-coupled receptors, receptor activation, intracellular trafficking, G protein-coupled receptor 120, The Bile Salt Export Pump, the lxr/srebp-1c signaling pathway, atherosclerosis, heart tissue and PKC. The third section, genetic machinery and its function, addresses DNA methylation, glucokinase gene variations, splicing, polymorphisms, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer protein and peroxidation-derived aldehydes. The relation between lipids and disease are also explored in this section The book also addresses emerging fields of molecular biology and presents important discoveries related to diet and nutritional health. Summarizes molecular nutrition in health as related to fatsDiscusses impact of fats on cancer, heart disease, dementia, respiratory, and intestinal diseaseIncludes preclinical, clinical and population studiesCovers the genome, the whole body and whole communitiesncludes key facts, a mini dictionary of terms, and summary points INDICE: Part 1: General and Introductory Aspects 1. Nomenclature, classes and functions of lipids and lipid-related molecules 2. Dietary lipids and lipid metabolism: an overview 3. Essential fatty acid deficiency in humankind 4. High fat diets, choline and cholesterol metabolism 5. Lipid membranes 6. Trans and saturated fatty acid levels in the blood and impact of diet 7. Fat-soluble vitamins and importance in the diet 8. Lipid emulsions in artificial nutrition 9. Fatty acid intake and cancer risk 10. Monounsaturated fatty acids and cancer 11. Combining omega-3 fatty acids and long-chain monounsaturated fatty acids in diets and effects in health 12. Lipid peroxidation and impact of products on 13. Sterols, stanols and statins 14. Hepatic steatosis 15. Lipids in emulsions 16. Omega-3 supplements and cardiovascular disease 17. Trans-fatty acids and coronary heart disease 18. Lipds and dementia 19. Intestinal disease and bioactive lipids 20. Respiratory disease and dietary lipids 21. Long chain polyunsaturated fatty acids in pregnancy 22. Lipid-based nutrient supplements to children 23. Lactation and dietary lipids 24. Public health aspects of nutritional counseling and low-density lipoprotein cholesterol 25. Public health impact of fatty acid intake and depression 26. Lipids in the diet and capillary dysfunction: public health implications of Alzheimer's disease 27. C-reactive protein and plasma fatty acids: public health concerns and implications Part 2: Molecular Biology of the Cell 28. The mitochondria as a site of fatty acid beta-oxidation 29. Subcellular organelles: lysosomes in lipid accumulation 30. Subcellular organelles: lipid droplets 31. Lipid raft formation in macrophages 32. Lipid rafts in vascular endothelial cells 33. G protein-coupled receptor 120 (GPR120) 34. The Bile Sale Export Bump (BSEP) and lipid metabolism 35. Dietary fat and insulin: from cell exposure to transcriptional processes 36. Stearoyl-CoA desaturase indexes as biomarkers in cardiometabolic 37. Polyunsaturated fatty acids and mTOR signaling Prof. P.A. Marignani 38. N-6 polyunsaturated fatty acids and brain polyunsaturated fatty acids 39. Fatty acid amide ligands and G protein-coupled receptors 40. Dietary fatty acids and weight gain via receptor activation: a focus on the endocannabinoid system 41. Lipid composition and intracellular trafficking 42. The LXR/SREBP-1c signaling pathway, lipids and atherosclerosis 43. Heart tissue, lipids and PKC activation 44. Brain signaling and monounsaturated dietary lipids compared to polunsaturated Part 3: Genetic Machinery and Its Function 45. Intracerebral hemorrhages and genetic loci for serum total, LDL, and HDL cholesterol, and triglycerides 46. DNA methylation patterns and n-3 fatty acid intake 47. Glucokinase gene variations and fish oil 48. Dietary free fatty acids and gene expression in adipocytes and other cell types 49. Alternative splicing and cholesterol 50. Polymorphisms in triacylglycerol metabolism 51. Fatty acids and desaturase gene polymorphism in elderly 52. Polymorphisms of the CETP gene and public health implications 53. Fatty acid binding protein 2 genes and public health implications for diabetes 54. Polymorphisms in fatty acid beta-oxidation 55. Cholesteryl ester transfer protein polymorphisms 56. Micro RNA (miRNA) and lipid metabolism 57. Transcriptomics and n-3 polyunsaturated fatty acids supplementation 58. Transcriptional factor modulation by lipid peroxidation-derived aldehydes
- ISBN: 9780128112977
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 1072
- Fecha Publicación: 05/11/2018
- Nº Volúmenes: 1
- Idioma: Inglés